Revistas
Revista:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN:
1661-6596
Año:
2023
Vol.:
24
N°:
15
Págs.:
11938
Acute intermittent porphyria (AIP) is a metabolic disorder caused by mutations in the porphobilinogen deaminase (PBGD) gene, encoding the third enzyme of the heme synthesis pathway. Although AIP is characterized by low clinical penetrance (similar to 1% of PBGD mutation carriers), patients with clinically stable disease report chronic symptoms and frequently show insulin resistance. This study aimed to evaluate the beneficial impact of nutritional interventions on correct carbohydrate dysfunctions in a mouse model of AIP that reproduces insulin resistance and altered glucose metabolism. The addition of spores of Bacillus coagulans in drinking water for 12 weeks modified the gut microbiome composition in AIP mice, ameliorated glucose tolerance and hyperinsulinemia, and stimulated fat disposal in adipose tissue. Lipid breakdown may be mediated by muscles burning energy and heat dissipation by brown adipose tissue, resulting in a loss of fatty tissue and improved lean/fat tissue ratio. Probiotic supplementation also improved muscle glucose uptake, as measured using Positron Emission Tomography (PET) analysis. In conclusion, these data provide a proof of concept that probiotics, as a dietary intervention in AIP, induce relevant changes in intestinal bacteria composition and improve glucose uptake and muscular energy utilization. Probiotics may offer a safe, efficient, and cost-effective option to manage people with insulin resistance associated with AIP.
Otros (PIUNA, fundaciones, contratos…)
Título:
Intervención nutricional con probióticos dirigida a restablecer el metabolismo de carbohidratos y la hiperinsulinemia: una nueva perspectiva traslacional para el manejo de la porfiria aguda intermitente (PROPAI)
Código de expediente:
FD Eugenio RP 2023
Investigador principal:
Isabel Solares Fernández
Financiador:
FUNDACIÓN EUGENIO RODRÍGUEZ PASCUAL
Convocatoria:
2023 FD Eugenio Rodríguez Pascual - Proyectos de Investigación
Fecha de inicio:
01/12/2023
Fecha fin:
30/11/2025
Importe concedido:
24.500,00€